Abstract
BackgroundA negative status following confirmatory Early Infant Diagnosis (EID) is the desired pediatric outcome of prevention of Mother to Child Transmission (PMTCT) programs. EID impacts epidemic control by confirming non-infected HIV-exposed infants (HEIs) and prompting timely initiation of ART in HIV-infected babies which improves treatment outcomes.ObjectivesWe explored factors associated with EID outcomes among HEI in North-Central Nigeria.MethodThis is a cross-sectional study using EID data of PMTCT-enrollees matched with results of HEI’s dried blood samples (DBS), processed for DNA-PCR from January 2015 through July 2017. Statistical analyses were done using SPSS version 20.0 to generate frequencies and examine associations, including binomial logistic regression with p < 0.05 being statistically significant.ResultsOf 14,448 HEI in this analysis, 51.8% were female and 95% (n = 12,801) were breastfed. The median age of the infants at sample collection was 8 weeks (IQR 6–20), compared to HEI tested after 20 weeks of age, those tested earlier had significantly greater odds of a negative HIV result (≤ 6 weeks: OR = 3.8; 6–8 weeks: OR = 2.1; 8–20 weeks: OR = 1.5) with evidence of a significant linear trend (p < 0.001). Similarly, HEI whose mothers received combination antiretroviral therapy (cART) before (OR = 11.8) or during the index pregnancy (OR = 8.4) had significantly higher odds as compared to those whose mothers did not receive cART. In addition, HEI not breastfed had greater odds of negative HIV result as compared to those breastfed (OR = 1.9).ConclusionscART prior to and during pregnancy, earlier age of HEI at EID testing and alternative feeding other than breastfeeding were associated with an increased likelihood of being HIV-negative on EID. Therefore, strategies to scale-up PMTCT services are needed to mitigate the burden of HIV among children.
Highlights
Infant Diagnosis (EID) that yields a negative result is a desired pediatric outcome of programs designed to prevent Mother to-Child Transmission (MTCT) of HIV [1]
Conclusions: combination anti-retroviral treatment (cART) prior to and during pregnancy, earlier age of HIV-exposed infants (HEIs) at Early Infant Diagnosis (EID) testing and alternative feeding other than breastfeeding were associated with an increased likelihood of being HIV-negative on EID
Strategies to scale-up prevention of Mother to Child Transmission (PMTCT) services are needed to mitigate the burden of HIV among children
Summary
Infant Diagnosis (EID) that yields a negative result is a desired pediatric outcome of programs designed to prevent Mother to-Child Transmission (MTCT) of HIV [1]. For their HIV-infected mothers, staying alive and retained in care with good ART adherence and periodically demonstrated enduring suppression of HIV is the end goal [2]. EID impacts epidemic control by confirming non-infected HEIs and prompting timely initiation of ART in HIV-infected babies which improves. EID impacts epidemic control by confirming noninfected HIV-exposed infants (HEIs) and prompting timely initiation of ART in HIV-infected babies which improves treatment outcomes
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