Abstract
2010. Dimerization and its role in GMP formation by human guanylate binding proteins. Biophy. J. 99:2235–2244. Fig. 1: Dimerization and Its Role in GMP Formation by Human Guanylate Binding ProteinsAbdullah et al.Biophysical JournalOctober 06, 2010In BriefThe mechanism of oligomerization and its role in the regulation of activity in large GTPases are not clearly understood. Human guanylate binding proteins (hGBP-1 and 2) belonging to large GTPases have the unique feature of hydrolyzing GTP to a mixture of GDP and GMP with unequal ratios. Using a series of truncated and mutant proteins of hGBP-1, we identified a hydrophobic helix in the connecting region between the two domains that plays a critical role in dimerization and regulation of the GTPase activity. Full-Text PDF Open Archive
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