Correction

Abstract

HomeArteriosclerosis, Thrombosis, and Vascular BiologyVol. 24, No. 3Correction Free AccessCorrectionPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessCorrectionPDF/EPUBCorrection Originally published11 Jun 2018https://doi.org/10.1161/01.atv.0000530593.52196.94Arteriosclerosis, Thrombosis, and Vascular Biology. 2004;24:618This article corrects the followingHepatic Catabolism of Remnant Lipoproteins: Where the Action IsIn the January 2004 issue of Arteriosclerosis, Thrombosis, and Vascular Biology, in Figure 1 of the Editorial by Dr. Heistad (Arteriosclerosis, Thrombosis, and Vascular Biology, 2004; pp 1–3), the impact factor is provided for T&H,but the legend should indicate correctly Thrombosis and Haemostasis.In the February 2004 issue, in the Editorial by Havel and Hamilton (Hepatic Catabolism of Remnant Lipoproteins: Where the Action Is; pp 213–215), an oversight in the production process allowed the publishing of an incomplete figure.The complete, correct figure, as it should have published, is shown below. All online versions of this Editorial have been corrected to include the complete figure. The Publisher apologizes for the error.Download figureDownload PowerPointTop left, Receptor-mediated uptake and intracellular processing of triglyceride-rich remnants and cholesteryl ester-rich LDL in rat liver (1988 version), showing passage of lipoproteins through fenestrae in the sinusoidal endothelium, followed by binding to endocytic receptors (Y) on hepatocytic microvilli projecting into the space of Disse (SD). The endocytic receptors migrate with their cargo to coated pits at the microvillar bases where they undergo endocytosis to form primary endosomes. After loss of the clathrin coat and endosome-fusion, the lipoproteins dissociate from the receptors at the acidic pH within the endosome. The lipoproteins are transported within the maturing endosomes toward the biliary (apical) pole of the cells, forming multivesicular bodies (MVB) (late endosomes), whereas the excess surface membrane resulting from endosome-fusion forms recycling endosomes that carry the receptors back to the basolateral surface of the cell (modified from Figure 1 in Havel RJ, Hamilton RL. Hepatocytic lipoprotein receptors and intracellular lipoprotein catabolism. Hepatology. 1988;8:1689–1704.). Top right (2003 version), Enlargement of a basolateral microvillus and adjacent endothelial cell (E), showing that chylomicron and large VLDL remnants pass through endothelial cell-fenestrae to the space of Disse where they bind initially to proteoglycan-bound apo E and hepatic lipase as well as LDLR, all of which are anchored to the microvillar membrane. Proteoglycan-bound hepatic lipase binds and hydrolyzes remnant-lipids, increasing exposure of the endocytic receptor-binding domain of apo E. Hepatic lipase can also act as a ligand for the endocytic receptors. Additional proteoglycan-bound apo E on microvilli acquired by the remnants increases the affinity of the remnant particles for LRP. The extent to which proteoglycans, hepatic lipase, and surface apo E themselves undergo endocytosis with the remnant particles is unknown. Normally, the surface density of LRP greatly exceeds that of LDLR, but only LDLR can readily bind remnants without further modification in the space of Disse. Bottom left, Thin section electron micrograph of normal rat liver illustrating the basolateral surface of hepatocytes (H) projecting numerous microvilli into the space of Disse. Plasma, including lipoproteins up to ∼200 nm diameter in the sinusoid, exchanges freely with the space of Disse through fenestrae (arrows) in the endothelium (E). ×18 000 diameters. Bottom right, Ultracryothin section of normal rat hepatocyte space of Disse showing microvilli decorated with 5-nm colloidal gold complexed with affinity-purified rabbit polyclonal anti-LRP from rat liver.10 ×90 000 diameters. Previous Back to top Next FiguresReferencesRelatedDetailsCited By Wu F, Wan Y, Wang L, Zhou L, Ma N and Qian W (2021) Construction of Optical Interference Fibrin and Thrombolysis Analysis with Silica Colloidal Crystal Films, Langmuir, 10.1021/acs.langmuir.1c01020, 37:23, (7264-7272), Online publication date: 15-Jun-2021. Related articlesHepatic Catabolism of Remnant Lipoproteins: Where the Action IsRichard J. Havel, et al. Arteriosclerosis, Thrombosis, and Vascular Biology. 2004;24:213-215 March 2004Vol 24, Issue 3 Advertisement Article InformationMetrics https://doi.org/10.1161/01.atv.0000530593.52196.94 Originally publishedJune 11, 2018 PDF download Advertisement