Correction

Abstract

2012. Computational model of cytokinetic abscission driven by ESCRT-III polymerization and remodeling. Biophys. J. 102:2309-2320. The calculated value of the membrane affinity to the dome surface that is required for neck fission is ε ≈ 0.28mN/m and not ε ≈ 0.07mN/m as stated in the original text. This value is still smaller by an order of magnitude than the estimated value ε ≈ 3.45mN/m inferred from in vitro studies. The interpretation of the data stated in the original article is therefore unaffected. Computational Model of Cytokinetic Abscission Driven by ESCRT-III Polymerization and RemodelingElia et al.Biophysical JournalMay 16, 2012In BriefThe endosomal sorting complex required for transport (ESCRT)-III complex, capable of polymerization and remodeling, participates in abscission of the intercellular membrane bridge connecting two daughter cells at the end of cytokinesis. Here, we integrate quantitative imaging of ESCRT-III during cytokinetic abscission with biophysical properties of ESCRT-III complexes to formulate and test a computational model for ESCRT-mediated cytokinetic abscission. We propose that cytokinetic abscission is driven by an ESCRT-III fission complex, which arises from ESCRT-III polymerization at the edge of the cytokinetic midbody structure, located at the center of the intercellular bridge. Full-Text PDF Open Archive