Abstract
Correction: Which Circulating Antioxidant Vitamins Are Confounded by Socioeconomic Deprivation? The MIDSPAN Family Study
Highlights
Low circulating levels of ‘‘antioxidant’’ vitamins, such as vitamin C, are associated with increased risk of atherothrombotic events in prospective studies of general populations [1]
Plasma vitamin C and carotenoids have strong inverse associations with adulthood markers of social deprivation, whereas vitamin A and E appear positively related to specific adverse lifestyle factors
These findings should help researchers better contextualize blood antioxidant vitamin levels by illustrating the potential limitations associated with making causal inferences without consideration of social deprivation
Summary
Low circulating levels of ‘‘antioxidant’’ vitamins, such as vitamin C, are associated with increased risk of atherothrombotic events in prospective studies of general populations [1]. Randomised controlled trials of supplements of antioxidant vitamins have far failed to show any consistent efficacy in reducing vascular risk or cancer [7,8,9,10,11,12,13]. This failure to reduce risk is unlikely to be only due to insufficient study length [8,12]. We aimed to compare to what extent a range of antioxidant vitamins and carotenoids are associated with adulthood and childhood markers of socioeconomic deprivation and to adverse lifestyle factors
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