Correction to 'Shape, form, function and Leishmania pathogenicity: from textbook descriptions to biological understanding'.

Abstract

Open AccessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Sunter Jack and Gull Keith 2018Correction to ‘Shape, form, function and Leishmania pathogenicity: from textbook descriptions to biological understanding’Open Biol.8180134180134http://doi.org/10.1098/rsob.180134SectionOpen AccessCorrectionCorrection to ‘Shape, form, function and Leishmania pathogenicity: from textbook descriptions to biological understanding’ Jack Sunter Jack Sunter http://orcid.org/0000-0002-2836-9622 Google Scholar Find this author on PubMed Search for more papers by this author and Keith Gull Keith Gull Google Scholar Find this author on PubMed Search for more papers by this author Jack Sunter Jack Sunter http://orcid.org/0000-0002-2836-9622 Google Scholar Find this author on PubMed Search for more papers by this author and Keith Gull Keith Gull Google Scholar Find this author on PubMed Search for more papers by this author Published:29 August 2018https://doi.org/10.1098/rsob.180134This article corrects the followingReview ArticleShape, form, function and Leishmania pathogenicity: from textbook descriptions to biological understandinghttps://doi.org/10.1098/rsob.170165 Jack Sunter and Keith Gull volume 7issue 9Open Biology13 September 2017Open Biol.7, 170165. (Published online 13 September 2017). (doi:10.1098/rsob.170165)A correction is required to table 2 of our above review. All the authors gave their consent to this correction.The correct version of table 2 is as follows:Table 2.Summary of morphological and/or motility mutants in Leishmania. Collapse proteingeneIDphenotypeconserved across Leishmania species on TriTrypDBv33development in sand fliespathogenicity in macrophagespathogenicity in animalsreferencePFR2LmjF.16.1425/1427/1430PFR-2 knockout cells had an altered flagellar beat with a reduced swimming velocityyesnot donenot donenot done[66]PFR1LmjF.29.1750/1760/1770Both PFR-1 knockout cells and PFR1/2 double knockout cells had an altered flagellar beat with a reduced swimming velocityyesnot donenot donenot done[67]ARL-3ALdBPK_290950.1Cells overexpressing a constitutively ‘active’ form of ARL-3A were immotile with short flagella and flagellum length was inversely proportional to mutant protein expressionyesunable to develop in sand fliesno change in macrophage infectivitynot done[68,18]MKKLmxM.08_29.2320MKK knockout cells had motile flagella, which was dramatically shorter and lacked a paraflagellar rod and also had shorter cell bodiesyesnot donenot donelong delay in lesion development[69]MPK9LmxM.19.0180MPK9 knockout cells had longer flagella, whereas overexpression led to a subpopulation with short/no flagellayesnot donenot donelesions developed slightly slower with knockout cells[70]DHC2.2LmxM.27.1750DHC2.2 knockout cells were immotile and had a rounded cell body. The flagellum that did not extend beyond the cell body and lacked a paraflagellar rod and other axonemal structuresyesnot donenot donenot done[71]MPK3LmxM.10.0490MPK3 knockout cells had shorter flagella with stumpy cell bodiesyesnot donenot doneno change in lesion development[72]Kin13-2LmjF.13.0130Kin13-2 knockout cells had longer flagella, whereas overexpression led to shorter flagella.yesnot donenot donenot done[73]ADF/cofilinLdBPK_290520.1ADF/cofilin (actin-depolymerizing factor) knockout cells were immotile with shorter flagella and a disrupted beat pattern. The cells were also shorter and wideryesnot donenot donenot done[74]KataninLmjF13.0960Cells overexpressing katanin-like homologue had shorter flagellayesnot donenot donenot done[75]SMP1LmjF.20.1310Loss of SMP1 caused a reduction in flagellum length and defects in motilityyesnot donenot donenot done[76]DC2LdBPK_323050.1DC2 knockout cells had shorter flagella with a disrupted ultrastructure and reduced motility. Moreover, the cell bodies were shorter with a more amastigote appearanceyesnot doneslight increase in macrophage infectivitynot done[77]Inhibitor of Serine Peptidase 1 (ISP1)LmjF.15.0300ISP1/2/3 triple knockout cells had longer flagella and were less motile than ISP2/3 double knockout cells. Moreover, the triple knockout had a greater number of cells with haptomonad, nectomonad and leptomonad morphologies. There was also a change in the shape of the anterior end of these cellsyesnot donereduced survival in macrophagesnot done[78] Previous Article VIEW FULL TEXT DOWNLOAD PDF FiguresRelatedReferencesDetailsRelated articlesShape, form, function and Leishmania pathogenicity: from textbook descriptions to biological understanding13 September 2017Open Biology This IssueAugust 2018Volume 8Issue 8 Article InformationDOI:https://doi.org/10.1098/rsob.180134PubMed:30158322Published by:Royal SocietyOnline ISSN:2046-2441History: Published online29/08/2018 License:© 2018 The Authors.Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. Citations and impact Subjectscellular biologymicrobiology molecular biology