Correction to 'Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels'.

Abstract

Open AccessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Proks Peter, Puljung Michael C., Vedovato Natascia, Sachse Gregor, Mulvaney Rachel and Ashcroft Frances M. 2016Correction to ‘Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels’Phil. Trans. R. Soc. B3712016033020160330http://doi.org/10.1098/rstb.2016.0330SectionOpen AccessCorrectionCorrection to ‘Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels’ Peter Proks Peter Proks Google Scholar Find this author on PubMed Search for more papers by this author , Michael C. Puljung Michael C. Puljung Google Scholar Find this author on PubMed Search for more papers by this author , Natascia Vedovato Natascia Vedovato Google Scholar Find this author on PubMed Search for more papers by this author , Gregor Sachse Gregor Sachse Google Scholar Find this author on PubMed Search for more papers by this author , Rachel Mulvaney Rachel Mulvaney Google Scholar Find this author on PubMed Search for more papers by this author and Frances M. Ashcroft Frances M. Ashcroft Google Scholar Find this author on PubMed Search for more papers by this author Peter Proks Peter Proks Google Scholar Find this author on PubMed Search for more papers by this author , Michael C. Puljung Michael C. Puljung Google Scholar Find this author on PubMed Search for more papers by this author , Natascia Vedovato Natascia Vedovato Google Scholar Find this author on PubMed Search for more papers by this author , Gregor Sachse Gregor Sachse Google Scholar Find this author on PubMed Search for more papers by this author , Rachel Mulvaney Rachel Mulvaney Google Scholar Find this author on PubMed Search for more papers by this author and Frances M. Ashcroft Frances M. Ashcroft Google Scholar Find this author on PubMed Search for more papers by this author Published:05 September 2016https://doi.org/10.1098/rstb.2016.0330This article corrects the followingReview ArticleRunning out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channelshttps://doi.org/10.1098/rstb.2015.0426 Peter Proks, Michael C. Puljung, Natascia Vedovato, Gregor Sachse, Rachel Mulvaney and Frances M. Ashcroft volume 371issue 1700Philosophical Transactions of the Royal Society B: Biological Sciences05 August 2016Phil. Trans. R. Soc. B371, 20150426 (2016; Published 4 July 2016) (doi:10.1098/rstb.2015.0426)The x-axis labels in figure 2b are incorrect. The corrected figure 2 is given below. Figure 2. Effect of rundown on single-channel KATP channel properties. (a) Representative 1 min recording of single Kir6.2-G334D/SUR1 channels at −60 mV in the cell-attached configuration (a, Po = 0.83) and after 5-min after patch excision (b, Po = 0.22). (b) Distributions of channel open times (i), closed times (ii) and burst duration (iii) before (pale grey bars) and after (dark grey bars) rundown. The distributions were fitted with probability density functions that gave the following values for the individual components. Before rundown: mean open time, 2.7 ms; three apparent closed states with mean values of 0.3 ms (98.5%), 2 ms (0.8%) and 12 ms (0.7%); and a single burst state with a mean duration of 120 ms. After rundown: mean open time 2.2 ms; five apparent closed states with mean values 0.3 ms (88.9%), 3 ms (3.3%), 19 ms (4.3%), 82 ms (3.1%) and 650 ms (0.4%); and three apparent burst states with mean durations of 23 ms (66%), 5 ms (20.5%) and 0.5 ms (13.5%). Vertical lines indicate the mean values for open times, short closed times and the major burst duration component, and illustrate that rundown has no effect on the intraburst closed times, but reduces the mean open time and burst duration. The methods and solutions used are as described in [6].Download figureOpen in new tabDownload PowerPoint Previous Article VIEW FULL TEXT DOWNLOAD PDF FiguresRelatedReferencesDetailsRelated articlesRunning out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels05 August 2016Philosophical Transactions of the Royal Society B: Biological Sciences This Issue05 September 2016Volume 371Issue 1702Theme issue ‘From DNA barcodes to biomes’ compiled and edited by Paul D. N. Hebert, Mehrdad Hajibabaei and Peter M. Hollingsworth Article InformationDOI:https://doi.org/10.1098/rstb.2016.0330PubMed:27481794Published by:Royal SocietyPrint ISSN:0962-8436Online ISSN:1471-2970History: Published online05/09/2016Published in print05/09/2016 License:© 2016 The Authors.Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. Citations and impact Subjectsbiophysicsphysiology