Abstract
[This corrects the article DOI: 10.18632/oncotarget.13817.].
Highlights
Ovarian cancer is a devastating malignancy, causing more deaths in the female US population compared to any other gynecologic cancer [1]
These results showed no clear role for caspase-8 or -9 in apoptosis in the response of PEO1 and PEO4 cells to cisplatin, they are downstream mediators of apoptosis and may be activated following treatment for a longer period (e.g. 24 hrs)
Bcl-2 family proteins are key modulators of the intrinsic mitochondrial-mediated apoptotic pathway and regulation of the activity of some members within this family have been associated with AKT phosphorylation and chemosensitivity in Epithelial ovarian cancer (EOC) [2, 8, 9]
Summary
Ovarian cancer is a devastating malignancy, causing more deaths in the female US population compared to any other gynecologic cancer [1]. 80% of EOC patients will soon relapse after first-line chemotherapy [3] This is in part due to the difficulty in diagnosis and treatment, the rising concern of drug resistance. The median progression-free survival (PFS) is 18 months before most of these patients relapse [2] Those with tumors that progress during or recur within 6 months of treatment are considered platinum-resistant [3]. Treatment failure is thought to be attributed to drug resistance in over 90% of cases with metastatic malignancy [2]. It can arise from multiple factors such as pharmacokinetic interactions, tumor micro-environment, and most likely, cancer-cell-specific abnormalities [2]. There is a dire need to better elucidate the mechanisms behind ovarian cancer drug resistance and how to overcome them
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