Abstract
The name of the second author was spelled incorrectly. The correct name is: Yu Jin Hah. In addition, the name of the third author was incorrectly represented in the Citation. The correct Citation is: Lee YJ, Hah YJ, Kang YN, Kang KJ, Hwang JS, et al. (2013) The Autophagy-Related Marker LC3 Can Predict Prognosis in Human Hepatocellular Carcinoma. PLoS ONE 8(11): e81540. doi:10.1371/journal.pone.0081540
Highlights
Hepatocellular carcinoma (HCC) is the sixth most common malignancy and the third most common cause of cancerrelated deaths worldwide [1]
Expression of light chain 3 (LC3), Beclin-1, glucose-regulated protein 78 (GRP78), and C/EBP homologous protein (CHOP) was positive in 21.1% (40/190), 5.8% (11/190), 31.6% (60/190), and 3.3% (6/190) of the hepatocellular carcinoma (HCC) specimens, respectively
The most frequent cause of HCC was the presence of hepatitis B virus (HBV) infection (137, 72.1%)
Summary
Hepatocellular carcinoma (HCC) is the sixth most common malignancy and the third most common cause of cancerrelated deaths worldwide [1]. In this study, we investigated the expression and extent of autophagy and ER stress-related markers in HCC and their influence on clinical characteristics and prognosis for each protein. Methodology: The expression of autophagy-related markers (LC3 and Beclin-1) and ER stress-related markers (GRP78 and CHOP) was analyzed by immunohistochemistry on tissues from completely resected specimens of 190 HCC patients. Their influence on clinicopathologic features and prognosis were evaluated using the chi-square test and Kaplan-Meier analysis. Principal Findings: LC3 expression was not correlated with TNM, BCLC stage, or Edmonson-Steiner grading, whereas it was correlated with longer overall survival (OS) (p = 0.039) and tended to be related with longer time to recurrence (TTR) (p=0.068) it did not show statistical significance. Conclusion: Our results suggest that the expression and extent of LC3 might be a strong prognostic factor of HCC, especially in patients with surgical resection
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