Abstract
Correction: Restricted Genetic Diversity of HIV-1 Subtype C Envelope Glycoprotein from Perinatally Infected Zambian Infants
Highlights
In the global HIV-1 pandemic, mother-to-child transmission (MTCT) of HIV-1 remains a significant problem in the resourceconstrained settings where the implementation of effective preventive and therapeutic strategies is still not widely available
Our results indicate that a strong genetic bottleneck occurs during perinatal transmission of HIV-1 subtype C
As a result the newly transmitted viruses are less diverse and harbored significantly less glycosylated envelope. This suggests that viruses with the restricted glycosylation in envelope glycoprotein appeared to be preferentially transmitted during HIV-1 subtype C perinatal transmission
Summary
In the global HIV-1 pandemic, mother-to-child transmission (MTCT) of HIV-1 remains a significant problem in the resourceconstrained settings where the implementation of effective preventive and therapeutic strategies is still not widely available. More than 90% of the infected children under the age of 15 are living in sub-Saharan Africa, where HIV-1 subtype C is the most prevalent and account for more than 60% of infections. Given the high prevalence of HIV-1 subtype C infections, a better understanding of virus transmission is of significant importance. Mother-to-child transmission of HIV-1 remains a significant problem in the resource-constrained settings where anti-retroviral therapy is still not widely available. We analyzed the viral env quasispecies of six mother-infant transmission pairs (MIPs) and characterized the genetic features of envelope glycoprotein that could influence HIV-1 subtype C perinatal transmission
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