Abstract
[This corrects the article DOI: 10.18632/oncotarget.21109.].
Highlights
Over the past few decades, adenocarcinoma of the esophagogastric junction (AEG) has markedly increased in Western and Eastern countries [1,2,3,4,5]
C-terminal tensin-like (CTEN) plays a crucial role in tumor cell proliferation, migration, and invasion through its overexpression, which highlights its usefulness as a prognosticator and potential therapeutic target in AEG
Quantitative RT-PCR analysis was performed to test whether CTEN was overexpressed in gastric cancer cell lines compared with the normal organs (Figure 1A)
Summary
Over the past few decades, adenocarcinoma of the esophagogastric junction (AEG) has markedly increased in Western and Eastern countries [1,2,3,4,5]. Despite the improvement of diagnosis and treatment technologies over the past three decades such as extended radical resection and chemo and/or chemoradiotherapy, many AEG patients frequently develop metastasis and experience recurrence, and the long-term survival remains poor because of the aggressive and systemic nature of this disease [6]. Numerous genes have been analyzed to understand the molecular mechanisms of carcinogenesis and improve the clinical outcomes for adenocarcinoma of the esophagus and esophagogastric junction. To detect a novel treatment target for adenocarcinoma of the esophagogastric junction (AEG), we tested whether C-terminal tensin-like (CTEN), a member of the tensin gene family and frequently overexpressed in various cancers, acts as a cancer-promoting gene through overexpression in AEG
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