Abstract
Hypothesis/aims of study. Disorders of immune homeostasis, morphofunctional and ultrastructural changes of erythrocytes in endometriosis lead to hypoxia, impaired micro-rheological and hemostatic statuses, dysmetabolism, organ and system dysfunction, which may contribute to the systemic consequences of this disease. The aim of this study was to evaluate the immune status and protein/lipid spectrum of erythrocyte membranes, as well as to develop methods for the pharmacological correction of impaired parameters in patients with internal endometriosis.
 Study design, materials, and methods. Fifty-seven patients with verified grade I–II adenomyosis were examined, assessing some immune status parameters and determining protein and lipid fractions of circulating erythrocyte membranes before and after pharmacotherapy.
 Results. The changes in the immune status parameters and protein and lipid composition of erythrocyte membranes revealed in adenomiosis disrupt the functional activity of immunocompetent cells and erythrocytes.
 Conclusion. The proposed methods of pharmacotherapy are pathogenetically substantiated and contribute to the correction of both the chosen immune status parameters and structural and functional properties of red blood cells, while improving the quality of treatment of patients with adenomyosis.
Highlights
The changes in the immune status parameters and protein and lipid composition of erythrocyte membranes revealed in adenomiosis disrupt the functional activity of immunocompetent cells and erythrocytes
The role of metalloproteins and cytokines in the pathogenesis of external genital endometriosis in combination with hypothyroidism
Summary
The proposed methods of pharmacotherapy are pathogenetically substantiated and contribute to the correction of both the chosen immune status parameters and structural and functional properties of red blood cells, while improving the quality of treatment of patients with adenomyosis. Однако исследования по изучению изменений параметров структурно-функциональных свойств эритроцитов, иммунного статуса, возможности их коррекции при эндометриозе немногочисленны [6, 7, 16], что обусловливает целесообразность детального изучения данного вопроса. Целью исследования стали изучение у пациенток с аденомиозом состояния иммунного статуса, белково-липидного спектра мембраны эритроцитов и разработка способов коррекции нарушенных показателей. В третью подгруппу вошло 18 пациенток, дополнительно получавших Инозин + Никотинамид + Рибофлавин + янтарную кислоту (Цитофлавин) внутривенно капельно по 10 мл 2 раза в сутки 7 дней; меглюмина акридонацетат (Циклоферон) — 3 табл. Методом G.T. Dodge [18] получали мембраны эритроцитов, электрофоретическое разделение мембранных белков проводили по методу U.K. Laemli [19]. Клинико-инструментальные исследования и фармакологическую коррекцию проводили с информированного согласия пациенток на использование материалов лечебно-диагностических мероприятий, связанных с заболеванием, для научно-исследовательских целей.
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