Correction of hepatic dysfunction in an extensive deep burn model

Abstract

The ongoing increase of burn trauma rates urges elaboration of valid and effective methods of medical aid with actualization of pathogenetically-based intensive therapy. Burn disease is a peculiar nosologic form characteristic of local manifestations as well as critical systemic state with involvement of internal organs and systems with subsequent development of polyorganic insufficiency. Liver lesions in case of burn disease are multiform and often combine with disturbances of other organs yielding polyorganic insufficiency. Desintoxicating, hepatoprotector and organoprotector effects of succine acid - containing medicines used for prevention of hepatic failure were assessed in the present study in a model of extensive deep burn in comparison with standard therapy. The experiments involved 60 mature albino rats (180-200 g). Deep burns involving 20% of body surface caused hepatic dysfunction. Remaxol and Reamberin infusions’ effects were comparatively assessed. To evaluate desintoxicating and hepatoprotector effects of these medicines biochemical analysis of these rats’ blood serum was carried out on the 7th day after infliction of extensive deep burns. Alanine-aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transpeptidase activity and bilirubin concentration were assessed. Analyzing desintoxicating and hepatoprotector effects of Remaxol and Reamberin upon the morphologic structure of the liver in case of extensive deep burn one must admit these medicines are capable of moderate desintoxicating and hepatoprotector effects.