Abstract
Vitamin C has been shown to improve defective chemotaxis in Chediak - Higashi Syndrome. We evaluated its effect on NBs whose predisposition to sepsis is partly attributable to defective chemotaxis. Ten term NBs were treated with 4 doses of 100 mgs of VC q6 hrs starting on day 2 of life. Blood was obtained for study immediately before and after VC treatment. Chemotactic index (CI) and random migration index (RM) were determined by a modified Boyden's chamber technique. PMNs were deposited on a 3 μ millipore filter which divided the chamber into an upper compartment filled with Hank's solution (HS), and lower filled with a mixture containing AB serum, endotoxin and HS. Following incubation and staining a ratio of migrated cells to total cells was determined and termed CI. In a parallel run with HS on either side the ratio was termed RM. The result (table) indicates that CI and RM increased about 64% followingVC therapy, a difference significant at P<0.02. We conclude that Vitamin C by improving the PMN qualitatively may be a useful adjunct to the treatment of sepsis in NB infants in general and in leukopenic infants in particular.
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