Abstract
Today, in medical practice, a very promising direction of development can be the expansion of the range of primary and secondary neuroprotection drugs through the use of targeted synthesis of potential neuroprotective agents with analeptic effect. This is necessary to improve anesthetic safety during surgery and to alleviate post-anesthetic intoxication after anesthesia. Therefore, the aim of our study was to compare the neuroprotective activity of original derivatives of sulfur and nitrogen-containing heterocycles (heterosides) and reference drugs, which are already known in pharmacology (cerebroprotective agent with neurotrophic action ¾ cerebrocurin and nootropic drug with neuroprotective action ¾ noopept). In the course of the research, it was found that after ketamine anesthesia, the excitability of the central nervous system increases, the anxious behavior of animals increases, while the indicators of the research work of animals in the experiment sharply deteriorate. After 2 days or more (10 days) after the transferred ketamine anesthesia, a deterioration in mnestic functions was noted in this group of animals. With the introduction of 100 mg / kg of heteroside to a group of rats after ketamine anesthesia, the indicators of anxiety behavior and excitability of animals significantly decreased, their research activity increased, a pronounced antiamnestic effect was manifested, and the ability of animals to learn was increased as well. It also turned out that in terms of the degree of influence on the indicators of the cognitive-mnestic functions of the central nervous system, heteroside statistically significantly exceeds the comparison drugs cerebrocurin and noopept, which in turn showed high efficiency in reducing anxiety of animals, and also had an antiamnestic effect, but did not affect the ability of animals to learn.
Highlights
The degree of protection of the body from surgical trauma using various methods of anesthesia, as well as criteria for its adequacy, currently continue to be the one of the main subject of discussion
It was believed that effects of general anesthesia (GA) occur quickly and same quickly disappear, so after removing anesthetics from the body the brain returns to the preoperative state and patient wakes up, so the negative effects of GA on the central nervous system (CNS) in the post-anesthesia period decrease and disappear
General anesthesia can cause CNS damage in the postoperative period, among which a special place is occupied by postoperative cognitive dysfunction, which can develop in patients of different ages and in cases with a unencumbered psychoneurological history
Summary
The degree of protection of the body from surgical trauma using various methods of anesthesia, as well as criteria for its adequacy, currently continue to be the one of the main subject of discussion. Prophylactic neuroprotective therapy together with the selection of an adequate option of anesthesia, correction of hemodynamic disorders, level of blood gas exchange and homeostasis if necessary, is the most essential way to prevent neuronal damage or eliminate cognitive dysfunction, which has already occurred in the early postoperative period, while this this changes are potentially reversible [7; 8]. It is reasonable and promising to search among the derivatives of sulfur- and nitrogencontaining heterocycles (heterosides) - universal, harmless neuroprotectors with analeptic action, which can quickly and effectively accelerate the resuscitation of vital functions of the body, general detoxification, arrange detoxification
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