Abstract
Two funding organizations were incorrectly omitted from the Funding Statement. following sentence should be included with the Funding Statement: The article processing charge was funded by the German Research Foundation (DFG) and the Albert-Ludwigs-University Freiburg through the funding programme 'Open Access Publishing'.
Highlights
Kif3a is a subunit of hetero-trimeric Kinesin-2, a microtubule (MT) plus-end directed motor protein [1]
Kinesin-2 has been mostly studied in cilia where it functions to carry protein complexes along the microtubular axoneme from the base to the tip of the cilium in a process termed intraflagellar transport (IFT) that is required for cilia formation [3]
We report here that depletion of Kif3a slows the migration of MDCK cells
Summary
Kif3a is a subunit of hetero-trimeric Kinesin-2, a microtubule (MT) plus-end directed motor protein [1]. Hetero-trimeric Kinesin-2 consists of the two motor subunits Kif3a/Kif3b and the cargo-binding protein Kap3 [2]. The homodimeric kinesin-2 subunit Kif, which cooperates with Kif3a in ciliary transport of C. elegans sensory neurons, affects the polymerization and stability of microtubules and has been implicated in epithelial morphogenesis [9]. These observations raise the possibility that Kif3a and hetero-trimeric kinesin-2 play a role in microtubular transport and MT dynamics outside the cilium
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