Abstract
[This corrects the article DOI: 10.18632/oncotarget.22160.].
Highlights
Esophageal cancer (EC) is one of the most common digestive malignant tumors and the sixth main cause of cancer-related death worldwide [1, 2]
Gene expression profile GSE20347 was downloaded from Gene Expression Omnibus (GEO) database, including 17 EC samples and their paired adjacent noncancerous samples
Normalized Unscaled Standard Errors (NUSE) and Relative Log Expression (RLE) of these data after standardization were shown in Figure 1A and Figure 1B
Summary
Esophageal cancer (EC) is one of the most common digestive malignant tumors and the sixth main cause of cancer-related death worldwide [1, 2]. As with other malignant tumors, the occurrence and development of EC is a complex process with multi-step and multiple factors and www.impactjournals.com/oncotarget the molecular pathogenesis has not been fully elucidated [4,5,6]. Transcriptome is a set of all RNA transcripts including mRNA, tRNA, rRNA and non-coding RNA such as miRNA produced in one or a population of certain type of cells [10]. Unlike genome, which is roughly fixed for a certain type of cells, the transcriptome can vary with external environmental condition and it is considered to be highly dynamic. Transcriptomic changes inherit from genomic information and take place before the proteomic level. Understanding of this crucial stage of genomic information process is of most importance for us to unveal the mechanisms of tumorigenesis. We purposed the idea of dynamic transcriptome and put it forward to the study of EC transcriptomics and establishment of gene expression regulation network
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