Abstract
Volume 5, no. 2, e00074-14, 2014, https://doi.org/10.1128/mBio.00074-14. R. P. Kincaid, Y. …
Highlights
We are unable to locate the original cell line reagents used in this work
We attempted to generate stable cell lines in the GM19240 B-cell background, but we have repeatedly failed to generate these stable cell lines. These particular LCL cells appear to be refractory to efficient lentiviral transduction, and we conclude that the data forming the foundation of the original interferon-suppression-of-growth assay (Fig. 5B) are not reliable
We have confirmed that miR-S6S7 can modulate effects of type I interferon on an ISRE reporter in cells, we conclude that we have no reliable evidence regarding the activity of miR-S6S7 on cell growth
Summary
Major conclusions from the original manuscript remain valid. These include the following: (i) simian foamy viruses (SFVs) encode miRNAs, (ii) SFV miRNAs arise via a noncanonical mode of biogenesis, and (iii) two SFV miRNAs share sequence identity and functionality in regulating target transcripts in common with the lymphoproliferative and immunosuppressive host miRNAs miR-155 and miR-132. Correction for Kincaid et al, “Noncanonical MicroRNA (miRNA) Biogenesis Gives Rise to Retroviral Mimics of Lymphoproliferative and Immunosuppressive Host miRNAs” Sullivana aThe University of Texas at Austin, Molecular Biosciences, Austin, Texas, USA bInstitut für Virologie und Immunbiologie, Universität Würzburg, Würzburg, Germany
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