Correction for Haid et al., "Identification of a Human Respiratory Syncytial Virus Cell Entry Inhibitor by Using a Novel Lentiviral Pseudotype System".

Abstract

Volume 90, no. 6, p. 3065–3073, 2016, https://doi.org/10.1128/JVI.03074-15. We recently uncovered a systemic error in our report describing lentiviral pseudoparticles decorated with functional respiratory syncytial virus (RSV) envelope proteins. It has been described that lengthy cytoplasmic tails of viral envelope proteins can preclude efficient lentiviral pseudotyping. Considering this, we initially created a full-length and a C-terminally truncated variant of the RSV F protein. Initial experiments comparing these constructs did not reveal gross differences in lentiviral pseudotyping between full-length and truncated RSV F proteins. Now we have uncovered an early mix-up between these constructs. Consequently, all experimental data presented in Fig. 1 to 4 were obtained with a truncated RSV F protein, which we now designate RSV F trc. Moreover, RSV F-derived constructs such as RSV F K394R (Fig. 2 and 4) and RSV F K272E (Fig. 2 and 4) were created in the context of this truncation mutant and are now designated RSV F trc K394R and RSV F trc K272E.