Abstract
While the assay of immunogiobulin A (igA) in serum is well standardized, the determination of secretory IgA (slgA) remains a problem [1]. The presence of free secretory component (SC) complicates direct assay when anti-SC sera are used [2]. In addition, slgA polymorphism interferes with methods based on anti-or chain sera, and a correction factor must be used to calculate the concentrations of total IgA obtained with a monomeric IgA (mlgA) standard [3]. The value of this correction factor differs for single radial immunodiffusion (SRID), electroimmunodiffusion (EID), radioimmunologic assay and immunonephelometry [4-7]. We propose correction factors for use in determining IgA in colostrum and feces. They are given for both commercial IgA standards and for those prepared in our laboratory.
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