Abstract
Correction: Evaluation of a Novel Thermosensitive Heparin-Poloxamer Hydrogel for Improving Vascular Anastomosis Quality and Safety in a Rabbit Model
Highlights
Vascular anastomosis is the cornerstone of vascular, cardiovascular and transplant surgery [1]
HP copolymer was synthesized by conjugating mono amine-terminated Poloxamer (MATP) to heparin using EDC and NHS as coupling agents
Several laboratories have demonstrated that heparin can suppress the entry of smooth muscle cells (SMC) into a proliferative S-phase in response to some mitogens, but their mode of action remains unclear [37,38]
Summary
Vascular anastomosis is the cornerstone of vascular, cardiovascular and transplant surgery [1]. During the following 100 years, various new techniques developed, including medical adhesive anastomosis, cuff vascular anastomosis, built-in soluble stent method and laser welding method [3,4,5,6,7,8]. Restenosis and thrombosis remain significant limitations to the development of vascular anastomosis, especially for small blood vessels [9,10,11,12,13]. Causing necessity for further intervention, restenosis has clinical and economic implications. According to the response-to-injury hypothesis [15], restenosis is caused by intimal hyperplasia due to proliferation and migration of vascular smooth muscle cells (SMC) from the media into the intima. LMWH may inhibit cell proliferation and intimal hyperplasia [16]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
