Abstract
Correction: Ethanol Affects Network Activity in Cultured Rat Hippocampus: Mediation by Potassium Channels
Highlights
Alcohol abuse is a major social and medical burden in western society
In the present study we examined the dose-response effects of ethanol on spontaneous activity in networks of cultured hippocampal neurons, and wish to propose that small potassium (SK) channels are a major target of low concentrations of ethanol to affect activity of the network
Ethanol at low concentrations produced a persistent rise in network activity, which was strikingly different from that produced by high ethanol concentration, which blocked activity altogether
Summary
Alcohol abuse is a major social and medical burden in western society. Extensive neurobiological research has yielded a variety of synaptic and non-synaptic mechanisms affected by exposure to ethanol. There is a growing consensus that a major target for the action of ethanol is the inhibitory GABAergic synapse; as low concentrations of ethanol cause an increase in GABAergic transmission, either directly on synaptic and non-synaptic GABA receptors or via an effect on neurosteroids [2,3,4,5,6]. While there is an extensive research on possible molecular mechanisms on one end, and behavioral effects on the other, there is a paucity of information on the effects of ethanol on network activity [12] especially in small networks, isolated from the brain. In the present study we examined the dose-response effects of ethanol on spontaneous activity in networks of cultured hippocampal neurons, and wish to propose that small potassium (SK) channels are a major target of low concentrations of ethanol to affect activity of the network
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