Abstract

In Fig. 5A, the IL-12p40 panel was duplicated in the IFN-beta panel. Fig. 6A had splicing in the immunoblots between lanes three and four as well as lanes six and seven. The errors have been corrected: in Fig. 5A, the IL-12p40 panel and the IFN-beta panel were replaced and in Fig. 6A, the splices were indicated. This correction does not affect the results or conclusions of the study.Figure 6View Large Image Figure ViewerDownload Hi-res image Download (PPT) Death Domain-associated Protein 6 (Daxx) Selectively Represses IL-6 Transcription through Histone Deacetylase 1 (HDAC1)-mediated Histone Deacetylation in MacrophagesJournal of Biological ChemistryVol. 289Issue 13PreviewBackground: The role and underlying mechanism of Daxx in innate immunity remain to be investigated.Results: Daxx interacts with HDAC1 and binds to the promoter of IL-6. Daxx selectively represses IL-6 transcription through HDAC1-mediated histone deacetylation.Conclusion: Daxx selectively represses IL-6 transcription in TLR-triggered macrophages.Significance: Discovering a new negative regulator of IL-6 and providing insight to epigenetic mechanism of IL-6 production. Full-Text PDF Open Access

Highlights

  • the IL-12p40 panel was duplicated in the IFN-beta panel

  • This correction does not affect the results or conclusions of the study

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