Abstract
The physiological roles of the protease inhibitor SERPINB3 (SB3) are still largely unknown. The study was addressed to assess the biological effects of this serpin in vivo using a SB3 transgenic mouse model. Two colonies of mice (123 transgenic for SB3 and 148 C57BL/6J controls) have been studied. Transgenic (TG) mice showed longer survival than controls and the difference was more remarkable in males than in females (18.5% vs 12.7% life span increase). In TG mice decreased IL-6 in serum and lower p66shc in the liver were observed. In addition, TG males showed higher expression of mTOR in the liver. Liver histology showed age-dependent increase of steatosis and decrease of glycogen storage in both groups and none of the animals developed neoplastic lesions. In conclusion, the gain in life span observed in SB3-transgenic mice could be determined by multiple mechanisms, including the decrease of circulating IL-6 and the modulation of ageing genes in the liver.
Highlights
CORRIGENDUM: SERPINB3 is associated with longer survival in transgenic mice
Marika Crescenzi was omitted from the author list in the original version of this Article
The Author Contributions section should read ‘‘G.V. designed and performed the experiments, analyzed data and drafted the manuscript, M.R., G.C., C.T., A.C. preformed molecular biology experiments, S.Q., A.B. performed cell culture and western blot experiments, F.C. and M.C. performed histological analysis, N.T. handled the mice colony, C.M. carried out statistical analysis, A.A., A.G. were involved in the discussion and manuscript editing, P.P. was involved in the experimental design of the study, in the analysis of the data and manuscript editing
Summary
CORRIGENDUM: SERPINB3 is associated with longer survival in transgenic mice
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