Abstract
Correction: CD40 Gene Silencing Reduces the Progression of Experimental Lupus Nephritis Modulating Local Milieu and Systemic Mechanisms
Highlights
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder affecting multiple organ systems including the kidney, skin, lung, heart, hematopoietic system, and the brain
The effective transfection of small inhibitory RNA (siRNA) into dendritic cells (DC) was examined using Cy5.5 labeled siRNAs. siRNA molecules were efficiently delivered into the cell(100%)(data not shown);and as seen in fig. 1,Chol-siRNA-Cy5.5 had a significantly higher MFI than unmodified siRNA
After 45 min of DC incubation with Chol-siRNA, the molecule was totally located in the cytoplasm of the cell (Fig. 1)
Summary
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder affecting multiple organ systems including the kidney, skin, lung, heart, hematopoietic system, and the brain. Type IV glomerulonephritis leading to severe proteinuria, chronic renal failure and end-stage renal disease (ESRD) remains one of the most dreaded complications of SLE and is associated with significant morbidity and mortality [1,2]. Some studies have highlighted the importance of Tcells in stimulating the production of autoantibodies by B-cells in SLE [5]. Such stimulatory role by T-cells requires the presence of co-stimulatory signaling dyads, such as CD28/B7 or CD40/ CD154, without which B-cells may fail to proliferate or even undergo apoptosis [6,7]
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