Abstract
Correction: Absence of Functional Leptin Receptor Isoforms in the POUND (Lepr<sup>db/lb</sup>) Mouse Is Associated with Muscle Atrophy and Altered Myoblast Proliferation and Differentiation
Highlights
The cytokine-like hormone leptin is an important factor linking food intake with energy expenditure and body composition [1,2]
Leptin is secreted from fat cells, but skeletal muscle is a source of leptin [3], and serum leptin levels increase with increased muscle mass [4]
Myostatin ELISA kits were purchased from Alpco diagnostic and performed according to manufacturer’s protocol as we have described previously (33)
Summary
The cytokine-like hormone leptin is an important factor linking food intake with energy expenditure and body composition [1,2]. Leptin-deficiency increases expression of the muscle-wasting protein myostatin in myocytes [8], and the functional characteristics of skeletal muscle in leptin-deficient ob/ob mice have been noted to resemble those of aged rodents [9]. Serum leptin and muscle mass were found to decrease with age in C57BL6 mice [10], but leptin treatment increased muscle mass and muscle fiber size in aged mice [11]. Consistent with an anabolic role for leptin in the maintenance of skeletal muscle leptin treatment increases muscle mass in leptin-deficient ob/ob mice [14,15] and decreases the expression of catabolic factors such as the ubiquitin ligases muscle RING-finger protein-1 (MuRF1) and atrogin-1 (MAFbx) [16]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
