Correction: A Developmental Stage-Specific Switch from DAZL to BOLL Occurs during Fetal Oogenesis in Humans, but Not Mice.

Jing He,Richard A Anderson,Andrew J Childs,Hazel L Kinnell,Kayleigh Stewart,Stefan Schlatt

doi:10.1371/annotation/34304231-e54b-4080-af70-6f957f32d552

Abstract

[This corrects the article DOI: 10.1371/journal.pone.0073996.].

Highlights

The Deleted in Azoospermia (DAZ) gene family encodes three conserved RNA-binding proteins (DAZ, DAZL and BOLL), the expression of which is largely restricted to germ cells
We have examined the expression and distribution of the RNA-binding proteins DAZL and BOLL during human fetal oogenesis, revealing that whilst DAZL and BOLL gene expression overlaps using gestational age as the discriminator, DAZL and BOLL proteins are expressed by distinct populations of germ cells at different stages of maturation
We find a progressive pattern of expression as germ cells mature, with DAZL expressed in germ cells prior to, and in the early stages of meiotic prophase I, after which it is down-regulated and BOLL expressed

Summary

Introduction

The Deleted in Azoospermia (DAZ) gene family encodes three conserved RNA-binding proteins (DAZ, DAZL and BOLL), the expression of which is largely restricted to germ cells. DAZ arose from a duplication of the autosomal homologue Dazl (Deleted in azoospermia-like) [14], the expression of which is required at multiple stages of germ cell development in male and female mammals [1,11,15,16,17,18,19,20]. We show that Boll is transiently expressed in the germ cells of the fetal mouse ovary, but in striking contrast to the human, shows extensive co-expression in the same germ cells as Dazl Together, these data indicate that BOLL may have specific and important functions in regulating oogenesis in humans - distinct from those of DAZL - in contrast to its dispensability in mice

Results

Discussion

Ethics statement