Abstract
Laser speckle contrast imaging (LSCI) is highly sensitive to motion artifacts. The blood flow perfusion obtained by LSCI during tissue motion is a mixture with the artifacts due to inter-frame image misalignment and intra-frame image blurring. Previous studies mainly focused on registering the inter-frame image misalignment. To correct the overestimation of blood flow produced from the non-rigid tissue motion during the exposure of one frame, we proposed a method combining the strategy of heterogeneous regression analysis with the simultaneous assessment of tissue structure and laser speckle dynamics using dual-wavelength imaging to extract the blood flow from the measured mixture LSCI signal. Both the phantom and animal experiments suggest that this correction method can significantly reduce the impact of non-rigid motion and improve the accuracy of blood flow speed measurement in LSCI.
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