Abstract

Quantitative MRI measurements of the sagittal surface area of the corpus callosum (CC) in 72 preterm individuals tested at adolescence (14-15 years) were compared with verbal skills on neuropsychological tests in a study at the Institute of Psychiatry, De Crespigny Park, London, UK.

Highlights

  • Quantitative MRI measurements of the sagittal surface area of the corpus callosum (CC) in 72 preterm individuals tested at adolescence (14-15 years) were compared with verbal skills on neuropsychological tests in a study at the Institute of Psychiatry, De Crespigny Park, London, UK

  • In preterm individuals who had a periventricular hemorrhage in the neonatal period, the decrease in CC area was greater

  • Verbal IQ and verbal fluency scores were lower in male adolescents with reduced total mid-sagittal CC size and mid-posterior surface area

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Summary

Introduction

Quantitative MRI measurements of the sagittal surface area of the corpus callosum (CC) in 72 preterm individuals tested at adolescence (14-15 years) were compared with verbal skills on neuropsychological tests in a study at the Institute of Psychiatry, De Crespigny Park, London, UK. Total CC area in very preterm adolescents was 7.5% smaller than in controls (p=0.015). In preterm individuals who had a periventricular hemorrhage in the neonatal period, the decrease in CC area was greater. Verbal IQ and verbal fluency scores were lower in male adolescents with reduced total mid-sagittal CC size and mid-posterior surface area.

Results
Conclusion
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