Abstract
Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke. We measured infarct volume and behavioral outcome after middle cerebral artery occlusion in callosotomized rats and acallosal mice. Neither callosotomy in rats nor callosal agenesis in mice improved infarct volume or behavioral outcome after middle cerebral artery occlusion. These findings argue against a role for transcallosal projections in exacerbating focal cerebral ischemia.
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