Coronavirus disease 2019: current understanding of its pathophysiology and histopathological findings

Abstract

Although there have been many studies describing the clinical and histological features about the novel coronavirus disease 2019 (COVID-19) infection, there is lack of pathological data conducted on biopsies or autopsies. This review aimed to identify histopathological manifestation together with the pathophysiology of COVID-19. The COVID-19 epidemic is now a global health crisis. Close contact transmission has greatly accelerated the spread of the disease, resulting in severe morbidity and mortality. The patient may be completely asymptomatic or show clinical signs and symptoms as a result of numerous systems or organs being affected. The condition might manifest itself clinically as a mild, moderate, or severe illness. According to the system affection, the lesions differ in intensity and histological features. This review summarizes the current knowledge on COVID-19-associated histopathological manifestation in multiple organ systems.