Abstract
Infection with severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) is a rapidly spreading and devastating global pandemic. Many researchers are attempting to clarify the mechanisms of infection and to develop a drug or vaccine against the virus, but there are still no proven effective treatments. The present article reviews the common presenting hematological manifestations of coronavirus disease 2019 (COVID–19). Elucidating the changes in hematological parameters in SARS–CoV–2 infected patients could help to understand the pathophysiology of the disease and may provide early clues to diagnosis. Several studies have shown that hematological parameters are markers of disease severity and suggest that they mediate disease progression.
Highlights
The severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) contagion was first described in December 2019 when cases of pneumonia of an unidentified cause were reported in Wuhan, Hubei province, central China [1,2,3]
The source of the virus is currently understood to have been food products and wild animals that are available in the Huanan Seafood Wholesale Market, which was closed by the Chinese authorities on 1 January 2020 [1,2,3]
We separately address the effects on white blood cells (WBCs), red blood cells (RBCs), platelets (PLTs) and coagulation
Summary
The severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) contagion was first described in December 2019 when cases of pneumonia of an unidentified cause were reported in Wuhan, Hubei province, central China [1,2,3]. Group (CSG) of the International Committee on Taxonomy of Viruses (ICTV) suggested that the virus be designated “SARS–CoV–2”, as it bears many similarities to severe acute respiratory syndrome (SARS)–causing coronaviruses (SARS–CoVs) [6]. Molecular andafore–mentioned phylogenetic analyses of clinical samples from theinfectivity respiratory of infected the etiological factors underlying the severe pneumonia epidemics in Arabia patients have revealed that SARS–CoV–2 resembles two bat–borne SARS–like CoVs that had been [15]. Division of COVID–19 diagnoses into four categories, based primarily on the radiological results of the patients, has been proposed [31] Despite these various classification criteria, most studies still only distinguish between mild and severe (intensive care requiring) disease manifestation, aiming to identify factors which may predict the severity of disease and be applicable to COVID–19 diagnosis and monitoring of treatment
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