Abstract

The coronavirus (COVID-19) exhibits a wide diversity of clinical manifestations due to the close association between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the host immune mechanisms. SARS-CoV-2 viral clearance counts on adaptive immune responses, while innate immune populations such as dendritic cells (DCs) and macrophages have crucial roles in killing infected cells. Innate immune cells have vast pattern recognition receptors to induce different signaling pathways. Adaptive immune populations, including helper T cells (CD4+ T lymphocytes), cytotoxic T cells (CD8+ T lymphocytes), and B lymphocytes (sources of antibodies), can control infectious viruses to protect human bodies. In this review, how do the innate and adaptive immune systems recognize and respond to the invasion of the SARS-CoV-2 will be discussed.

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