Abstract
Coronary microvascular dysfunction (CMD), diagnosed by invasive coronary reactivity testing (CRT), is frequent in women with evidence of ischemia with non-obstructive coronary artery disease (INOCA), and may progress to heart failure with preserved ejection fraction (HFpEF). CS is a cBIN1 Score determined from plasma levels of cardiac origin cBIN1 protein which regulates cardiomyocyte calcium handling. A high CS indicates low cardiac muscle cBIN1, which is observed in both HFpEF and HFrEF. It is unknown whether CS is a useful biomarker for CMD.
Published Version
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