Coronary Microvascular Dysfunction is Associated with cBIN1 Score (CS) – Insights from the Women’s Ischemia Syndrome Evaluation – Coronary Vascular Dysfunction (WISE-CVD) Continuation Study

Abstract

Coronary microvascular dysfunction (CMD), diagnosed by invasive coronary reactivity testing (CRT), is frequent in women with evidence of ischemia with non-obstructive coronary artery disease (INOCA), and may progress to heart failure with preserved ejection fraction (HFpEF). CS is a cBIN1 Score determined from plasma levels of cardiac origin cBIN1 protein which regulates cardiomyocyte calcium handling. A high CS indicates low cardiac muscle cBIN1, which is observed in both HFpEF and HFrEF. It is unknown whether CS is a useful biomarker for CMD.