Abstract
Chronic inflammatory rheumatoid diseases (CIRD) such as rheumatoid arthritis, systemic lupus (SLE) erythematosus, and systemic sclerosis(SSC) are important risk factors for the development of ischaemic heart disease and important sources leading to high cardiovascular morbidity and mortality.In patients affected by CIRD, inflammation can affect coronary microvascular function and contribute to the development of myocardial ischemia and cardiovascular events, even in the absence of obstructive epicardial coronary artery disease.Understanding the molecular mechanism that underlies the development of coronary microvascular dysfunction (CMD) in CIRD is of fundamental importance for the identification of specific therapeutic targets.Here we review the pathogenesis, diagnosis, and treatment strategies of CMD in CIRD. Key words: Coronary microvascular dysfunction; Rheumatoid arthritis; Systemic lupus erythematosus; Systemic sclerosis; Microvascular angina
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