Abstract

Coronary atherosclerosis among patients with symptomatic or fatal myocardial ischemia is a diffuse and extensive process, and it affects all 4 of the major (right, left main, left anterior descending, and left circumflex) epicardial arteries. Histologic evaluation of 5-mm arterial segments reveals involvement of the entire lengths of the epicardial arteries, although the size of plaque may vary from segment to segment. The dominant component of atherosclerotic plaque among patients with symptomatic or fatal myocardial ischemia is fibrous tissue.

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