Abstract
The aim of this study was to determine the effects of stenting on downstream coronary microvessel structure in lean Ossabaw miniature swine. Bare metal stents were deployed in the left anterior descending (LAD) coronary artery of lean male Ossabaw miniature swine having a genetic propensity to obesity and metabolic syndrome. Four weeks after stent implantation, coronary microvessels (<150 μm diameter) downstream of either non‐stented (n=3) or stented (n=3) LAD were carefully isolated and mounted on a pressure myograph. After a 30‐minute equilibration period, coronary microvessel wall thickness and diameters were measured over a range of pressures (0–125 mmHg). Coronary microvessels downstream of bare metal stents exhibited a 20% decrease in luminal diameters (Non‐Stented: 123.8 ± 9.2 μm vs. Stented: 99.0 ± 12.1 μm p < 0.05), while wall thicknesses were preserved (Non‐Stented: 14.1± 1.2 μm vs. Stented: 13.5 ± 0.8 μm p > 0.05). The decrease in external diameter did not achieve statistical significance (Non‐Stented: 152.0 ± 10.7 μm vs. Stented: 126.0 ± 13.3 μm p = 0.05) These data suggest that bare metal stent deployment in the LAD causes downstream coronary microvessels to undergo eutrophic inward remodeling, which may contribute to chronically impaired coronary flow reserve. Support: NIH HL056046, Nationwide Children's Hospital to PAL; NIH RR013223, HL062552, UL1 RR025761, Purina TestDiet to MS.
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