Abstract
A study has been performed on 197 hearts obtained sequentially at autopsy. Coronary angiography and fixation were carried out at perfusion pressure of 100mm Hg. After X-ray, the coronarles were dissected from the heart and cleared in glycerol for detailed examination by stereomicroscopy. Sites of intramural haemorrhage and neovascularization were common and frequently these sites were found to be foci of chronic inflammation with classical cell infiltrates. Morphometric analyses reveal that wall thickness and narrowing of the lumen are related to focal inflammatory reactions in the coronary artery wall. Immunohistochemical studies show that the coronary wall contains at times IgM, IgG and IgA as well as C-reactive protein. Using these probes to "flag" active sites, electron microscopy of coronary intima has identified intranuclear viral bodies tentatively identified as belonging to the <i>Herpesviridae</i>
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