Abstract
Background Different common gene variants were related to coronary artery disease (CAD) in many studies. Yet, the relation of these loci to the severity of CAD is not completely elucidated. Methods We enrolled 520 subjects (315 CAD cases and 205 controls). CAD presence and extension were assessed by coronary angiography (CAG). Genotyping of five SNPs (namely, rs2230806 (1051G > A) in ABCA1 on chromosome 9, rs2075291 (553G > T) in ApoA5 on chromosome 11, rs320 in LPL on chromosome 8 intron (T → G at position 481), rs10757278 (c.22114477A > G), and rs2383206 (c.22115026 A > G) on chromosome 9p21 locus) was performed by allele-specific PCR. The degree and site of arterial lesions were used to classify patients, tested for association with CAD severity, and related to allele dosage. Results The polymorphisms rs2383206 and rs10757278 showed significant associations with 2- and 3-vessel coronary disease (p =0.003 and 0.006, respectively). The homozygous GG genotypes of rs10757278 was associated with higher frequency of left anterior descending (LAD), right coronary artery (RCA) and left circumflex (LCX) diseases (p =0.002, 0.016 and 0.002, respectively). The GG genotypes of rs2383206 were found in higher percentage in patients with left main (LM) trunk and left circumflex (LCX) diseases (p = 0.013 and 0.002, respectively). Conclusion SNPs rs10757278 and rs2383206 allele dosage could predict CAD severity in the Saudi Arab population.
Highlights
Despite major advances in patient management, coronary artery disease (CAD) remains a leading cause of death worldwide [1]
SNP: single nucleotide polymorphism; CAD: coronary artery diseases; VD: vessel disease; LM: left main; LAD: left anterior descending; RCA: right coronary artery; LCX: left circumflex. (p ≤ 0:001; odds ratios (ORs) = 1:952, 95% CI: 1.131–3.348 and p = 0:006; OR = 2:854, 95% CI: 1.264–6.192, respectively)
CAD cases and controls were precisely stratified according to the angiographic estimation of the number and/or degree of stenosis of coronary artery lesions
Summary
Despite major advances in patient management, coronary artery disease (CAD) remains a leading cause of death worldwide [1]. CAD underlies a composite group of syndromes caused by partial or complete cardiac muscle regional ischemia as a result of temporary or permanent cessation of blood flow in one or more of coronary arteries [2]. These can be diagnosed by clinical, laboratory, and angiographic assessment of the patients suffering from chest pain [3]. The homozygous GG genotypes of rs10757278 was associated with higher frequency of left anterior descending (LAD), right coronary artery (RCA) and left circumflex (LCX) diseases (p =0.002, 0.016 and 0.002, respectively). SNPs rs10757278 and rs2383206 allele dosage could predict CAD severity in the Saudi Arab population
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