Abstract
Background and objectives Diabetes mellitus is one of the most prevalent metabolic disorders worldwide. Cardiac angiogenesis disruption occurs in diabetes. Petroselinum crispum has antioxidant properties leading to its therapeutic attributes. Materials and methods Sixty-four male Wistar rats were randomly sorted into eight groups: control, extract groups (50, 100, and 150 mg/kg of P. crispum), diabetic, and diabetic+extract groups. Diabetes was induced by intraperitoneal injection of streptozotocin (50 mg/kg), and different doses of extract were administered intraperitoneal for 30 days. The serum level of vascular endothelial growth factor was determined by enzyme-linked immunosorbent assay method; nitrite oxide was measured by Griess assay; and capillary density in the heart was evaluated by immunohistochemistry assay. Results and conclusion The values of all parameters were reduced significantly in the diabetic group compared with the control group (P 0.05). The hydroalcoholic extract of P. crispum did not affect cardiac angiogenesis in normal and diabetic patients, which probably is due to the insufficient amounts of active ingredients, especially flavonoids available in P. crispum.
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