Coronarotropic properties of cyclic GABA derivative TZ-146

Abstract

In the experiments on isolated contracting, fibrillating, and strophanthin K-arrested cat hearts, TZ-146, cyclic derivative of gamma aminobutyric acid enhanced the outflow of perfusate. When testedin vivo, this preparation increased the indices of phasic coronary blood flow in dogs, surpassing the effects of reactive hyperemia, which characterizes the dilatory capacity of coronary vessels. Pharmacological analysis and experiments with bilateral vagotomy in cats and dogs suggest that coronarotropic effects of TZ-146 can result from activation of adenylate cyclase and accumulation of cAMP.