Corona Virus: An Immunological Perspective Review

Pandey Archna,Mehta Abhay,Nema Neeti,Singh Nimesh,Suthar Bharat

doi:10.23937/2378-3672/1410050

Abstract

As the world is seeing the plague of COVID-19, an illness brought about by a novel coronavirus, SARS-CoV-2, developing hereditary qualities and clinical confirmations recommend a comparative way to those of SARS and MERS. A course of viral particles enters the body through the nose, eyes or mouth. Breathing conveys a portion of these particles to the lower respiratory tract where the spike proteins of the coronavirus, acting like a key, lock into epithelial cells that line the respiratory tract just as those in the air sacs in the lungs.

Highlights

Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds
As the world is seeing the plague of COVID-19, an illness brought about by a novel coronavirus, SARS-CoV-2, developing hereditary qualities and clinical confirmations recommend a comparative way to those of SARS and MERS
SARS-CoV-2 can remain undetected longer than numerous influenza or coronaviruses and its spike proteins can pick up passage by opening the ACE2 protein on the lung cells

Summary

Introduction

Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds. In the most severe cases, systemic inflammatory response syndrome (SIRS) occurs as the protein-rich fluid from the lungs enters the bloodstream, resulting in septic shock and multi-organ failure This is often the cause of death for people who have succumbed to a COVID-19 infection. In SARS, there are hardly any upper respiratory tract symptoms, and viral units are rarely present outside the lungs This fact initially took the focus away from continuing to look for ACE2 receptors in the nose. Blood vessels around the air sacs become leaky in response to inflammatory chemicals that the white blood cells release This fluid puts pressure on the alveoli from outside and, in combination with the lack of surfactant, causes them to collapse. More antibodies confined from patients who have to endure MERS-CoV contamination have been portrayed, including MCA1, CDC-C2, CSC-C5, CDC-A2, CDC-A10, MERS-GD27, and MERS-GD33 [42,43]

Discussion

Findings

ICTV Taxonomy history