Abstract
The design and construction of a dedicated liquid chromatography—mass spectrometry instrument for detecting and assaying trace-level target compounds are described. It employs a microbore high-performance liquid chromatograph interfaced directly to a point-to-point high voltage corona discharge ionization source with a quadrupole mass analyser. Applications are described using reversed-phase chromatography for the detection of route-specific impurities in formulated medicinal preparations at the 5 ppb level for patent protection, and for the detection of biogenic amines in blood plasma without derivatization.
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