Abstract
Cornus officinalis Sieb. et Zucc. is part of the genus Cornus of the family Cornaceae. Ripening and dry fruits (Corni Fructus) are recognized as an essential herb medicine in the traditional Chinese medicine (TCM) and have been widely used for over 2000 years. This review provides a comprehensive summary of Corni Fructus (CF), including the botany, phytochemistry, traditional use, and current pharmacological activities. According to the basic theory of TCM, CF usually participates in various Chinese medicinal formulae to exert the essential roles in replenishing liver and kidney, arresting seminal emission and sweat. Based on modern pharmacological studies, about 90 compounds have been isolated and identified from CF. In vivo and in vitro experimental studies indicate that CF exhibits extensive pharmacological activities including hypoglycemic, antioxidant, anti-inflammatory, anticancer, neuroprotective, hepatoprotective, and nephroprotective activities. However, only about 18% of chemical constituents in CF were tested. It means the potential pharmacological activities and clinical values of CF need to be further investigated.
Highlights
Cornus officinalis Sieb. et Zucc., commonly known as Shan Zhu Yu/山茱萸, Asiatic Dogwood, and Japanese Cornel Dogwood, is a deciduous shrub or dungarunga in the genus Cornus
Tannins (40–69) During the isolation process, Corni Fructus (CF) was firstly homogenized in acetone and filtered to acquire an aqueous solution which was sequentially extracted with diethyl ether and ethyl acetate
CF is recognized as a fundamental constituent part of tonifying Yin and Yang prescription because of its harmonious and complementary features according to the basic theory of traditional Chinese medicine (TCM)
Summary
Cornus officinalis Sieb. et Zucc., commonly known as Shan Zhu Yu/山茱萸 (in Chinese), Asiatic Dogwood, and Japanese Cornel Dogwood, is a deciduous shrub or dungarunga in the genus Cornus (family Cornaceae). Can be found in Anhui, Gansu, Jiangsu, Jiangxi, Shandong, Shanxi in China, Korea, and Japan It usually grows in 400–1500 m high mountain slope, forest or forest edge. CF is usually combined with Radix Rehmanniae Praeparata, Dioscoreae Rhizoma, Alismatis Rhizoma, Moutan Cortex, Poria to make Liuwei Dihuang Wan (六味地黄丸) replenish liver and kidney Yin [3]. For patients with kidney deficiency, CF is frequently used with Radix Rehmanniae Praeparata, Dioscoreae Rhizoma, Cervi Cornu Pantotrichum, Psoraleae Fructus. Chemical constituents About 90 compounds have been isolated and identified from CF, including terpenoids, flavonoids, tannins, polysaccharides, phenylpropanoids, sterols, carboxylic acids, furans, and mineral substances. Tannins (40–69) During the isolation process, CF was firstly homogenized in acetone and filtered to acquire an aqueous solution which was sequentially extracted with diethyl ether and ethyl acetate. Naringenin Kaempferol Kaempferide Kaempferol-3-O-β-d-galactopyranoside Kaempferol-3-O-β-d-glucoside Kaempferol-3-O-β-d-rutinoside Quercetin Quercetin-3-O-β-d-galactopyranoside Quercetin-3-O-β-d-glucuronide Quercetin-3-O-β-d-glucuronide methyl ester Quercetin-3-O-β-d-(6-n-butyl glucuronide) (−)-Epicatechin-3-O-gallate Isoquercitrin
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
