Abstract
We present the applicability of high-speed swept source (SS) optical coherence tomography (OCT) for quantitative evaluation of the corneal topography. A high-speed OCT device of 108,000 lines/s permits dense 3D imaging of the anterior segment within a time period of less than one fourth of second, minimizing the influence of motion artifacts on final images and topographic analysis. The swept laser performance was specially adapted to meet imaging depth requirements. For the first time to our knowledge the results of a quantitative corneal analysis based on SS OCT for clinical pathologies such as keratoconus, a cornea with superficial postinfectious scar, and a cornea 5 months after penetrating keratoplasty are presented. Additionally, a comparison with widely used commercial systems, a Placido-based topographer and a Scheimpflug imaging-based topographer, is demonstrated.
Highlights
Anterior segment optical coherence tomography (OCT) was introduced in 1994 [1]
The fan distortion is associated with the OCT scanning system, which includes a pair of separate scanner mirrors and optical elements
To investigate the influence of fan and optical distortion of our OCT system in three dimensions, we performed a simple experiment using 2D gridlines printed on paper, which
Summary
Anterior segment optical coherence tomography (OCT) was introduced in 1994 [1]. It was based on a time domain OCT method presented three years earlier, in which the distribution of scattering points along the scanning beam is detected indirectly by varying the length of the reference arm of the Michelson interferometer [2]. Results from a prototype, based on 1310 nm superluminescent diode capable of covering larger portion of the anterior segment—entire cross-sectional information about the cornea—were reported in 2000 [4], and 5 years later a commercial 1310 time domain OCT system for anterior segment imaging was launched under the name Visante OCT (Carl Zeiss, Inc.). This is the most widely used OCT device for dedicated in vivo anterior segment imaging. Commercial Fourier domain OCT systems using a spectrometer (Spectral OCT –SOCT) have reached an axial resolution of 3–6 μm and imaging speed of 20,000–50,000 lines/s, they are not able to provide adequate assessment of anterior and posterior corneal topography because of significantly strong fringe washout and sensitivity drop off typical for SOCT [17,18,19]
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