Abstract
Instillation of epinephrine bitartrate, borate, and hydrochloride solutions in various clinically used strengths failed to produce corneal melanin pigmentation in rabbit eyes. Continuous exposure to the experimental drug using saturated Czech soft gel contact lenses also failed to induce pigmentation in the intact rabbit cornea. Repeated elevation of intraocular pressure by subconjunctival injection of hypertonic sodium chloride solution and abrasion of corneal epithelium resulted in pigment deposition. The appearance of pigment was obtained very much earlier with the use of oxidized epinephrine preparations. In the earliest stages, the pigment was detected only by histological examination. At later stages, slit-lamp biomicroscopy revealed the pigmentation, which eventually could be recognized on gross inspection.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
