Abstract
The eye and the brain have limited capacities for regeneration and as such, immune-mediated inflammation can produce devastating consequences in the form of neurodegenerative diseases of the central nervous system or blindness as a result of ocular inflammatory diseases such as uveitis. Accordingly, both the eye and the brain are designed to limit immune responses and inflammation â a condition known as âimmune privilegeâ. Immune privilege is sustained by physiological, anatomical, and regulatory processes that conspire to restrict both adaptive and innate immune responses.
Highlights
A striking example of immune privilege was reported by Abel who treated an 8-year old boy who had a 10 week history of ocular pain [1]
Dendritic Cells and Immune Privilege are exempt from immune rejection and that the anterior chamber (AC) of the eye is devoid of lymphatic drainage, which presumably isolates the interior of the eye from the systemic immune apparatus
We explored the potential role of CD11c+ DCs in the development of sympathetic loss of immune privilegeâ (SLIP) and the loss of ocular immune privilege by isolating CD11c+ CS from mice subjected to corneal nerve injury and adoptively transferring them to naĂŻve recipients
Summary
A striking example of immune privilege was reported by Abel who treated an 8-year old boy who had a 10 week history of ocular pain [1]. The second and astonishing finding was the conspicuous absence of inflammation in the anterior chamber of the eye in which the seedling had germinated. These two observations are in keeping with the principles of immune privilege: 1) the prolonged survival of a foreign tissue that would normally be rejected in conventional body sites and 2) the local quenching of inflammation. A more commonly recognized example of ocular immune privilege is the remarkable success of corneal allografts, which in uncomplicated cases enjoy a survival rate of 90% even though histocompatibility matching is not routinely practiced and the only immunosuppressive drugs are topically applied corticosteroids [2,3,4]. Two common misconceptions about immune privilege are that corneal transplants
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