Abstract

Abstract Purpose To study corneal keratocyte population after LASEK with mitomycin C (MMC) 15 months vs 3 months after surgery Methods Sixty eyes were included in this study, all of them treated with LASEK with intraoperative 0.02% MMC, divided into 2 groups. 32 eyes had LASEK performed 3 months before, versus 28 in the 15 months post‐op group. Keratocyte density was examined by using confocal microscopy in the anterior, mid and posterior stroma in both groups, and the mean density was compared with a control group of healthy eyes Results Keratocyte density in the anterior stroma was 16993,75+ 8001,7 cells/mm3 and 18529,1 + 2917,7 cells/mm3(p=0,3) in the 3 months and in the 15 months groups respectively, in the mid stroma it was 30783,3+ 9300 cells/mm3 in the 3 months and 20754,7 + 3615,3 cells/mm3 in the 15 months groups (p= 0,0001) and 30286,75+ 8321 cells/mm3and 19994+ 3085,9 cells/mm3 (p= 0,0001) in the posterior stroma in the 3 months and in the 15 months groups respectively. The comparison between the average densities through the whole cornea showed statistically significant difference between the 3 months vs 15 months group and 3 months vs normals, but it was not statistically significant different between 15 months vs normals Conclusion The changes in the corneal keratocyte population after LASEK + MMC seen in the early post‐op, seem to change towards the normal values 15 months after the procedure.

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