Abstract
Terahertz technology has shown broad prospects for measuring corneal water content, which is an important parameter of ocular health. Based on terahertz time-domain spectroscopy, a new indicator named characteristic ratio (CR) of the sum of low (0.2-0.7 THz) and high (0.7-1.0 THz) frequency spectral intensities, for characterizing corneal hydration is introduced in this work. CR is calculated from the real-time reflection spectra after error elimination of ex vivo human corneal stroma samples which is collected during dehydration under natural conditions (temperature: 22.4 ± 0.3°C; humidity: 20.0 ± 3%). The corresponding relationships between CR and corneal water content are reported. Comparing the linear fitting results with the published similar study, the coefficients of variation of the fitting slope and intercept are 39.4% and 27.6% lower, respectively. This indicates that this approach has the potential to achieve corneal water content in-vivo detection in the future.
Highlights
The stroma constitutes the largest portion (>90%) of cornea which is the outermost structure of the eye [1]
It has been demonstrated that Corneal tissue water content (CTWC) could significantly affect the tissue ablation rate of most popular keratorefractive surgeries, such as Laser-Assisted in situ Keratomileusis (LASIK), Laser-Assisted Sub-Epithelial Keratectomy (LASEK) and so on [9,10,11,12]
We showed the preliminary results of application of THz time domain spectroscopy for monitoring the long-time dynamics of corneal tissue drying and sensing corneal hydration
Summary
The stroma constitutes the largest portion (>90%) of cornea which is the outermost structure of the eye [1]. Many crucial characteristics including physical strength, shape stability and transparency of the cornea are mainly determined by the anatomic and biochemical properties of stroma [2,3]. Corneal tissue water content (CTWC) refers to the percentage of the moisture weight in corneal tissue to the tissue weight after drying. Various ophthalmic diseases, such as corneal edema and Fuch’s endothelial dystrophy [4,5] are accompanied by corneal hydration disorders [6,7,8]. CTWC is a vital parameter for clinical ophthalmic diagnoses and cornea-involved surgeries
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