Abstract
AbstractAn intraocular irrigating solution developed in India (Irrisol) has been reported to cause immediate corneal edema when used during cataract surgery. The purpose of this study was to evaluate this intraocular irrigating solution for endothelial toxicity and compare it to balanced salt solution (BSS), a similar irrigating solution used in the United States. Human and rabbit corneas were mounted for in vitro specular microscopy and endothelium perfused with Irrisol and BSS.The results of this study showed that Irrisol caused immediate corneal swelling, with marked destruction of the corneal endothelial cells when observed with scanning and transmission electron microscopy. Further analysis showed that the Irrisol had a lower surface tension (35 dynes/cm) compared to BSS (73 dynes/cm). High-performance liquid chromatographic (HPLC) analysis confirmed that the lower surface tension and the endothelial damage were due to the addition of benzalkonium chloride (BAC) (0.009%) in the Irrisol intraocular ir...
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
